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The Biology of Hair Loss

Summary & Participants

The average human scalp is covered by 100,000 hair follicles. If you've got all your hair, that may seem like a big number but when you start to lose it, the fate of each follicle becomes more important. What makes hair fall out? Join our two experts as they cast some light on the issue.

Medically Reviewed On: July 02, 2008

Webcast Transcript

ANGELA CHRISTIANO, PhD: Hair follicles are unique in human bodies, I think, because they're one of the only organs that actually undergoes a cycle, that goes through a cycling through sort of an immature phase, a growing phase and then a resting phase.

So usually you lose between 50 and 100 hairs a day normally, and you don't notice that, because they fall out in a random pattern. But when you start suffering from hair loss, as you mentioned earlier, each one of those becomes important. Definitely.

DAVID FOLK THOMAS: So at any given time you're actually having new hairs growing into your scalp for the first time -- a new cycle of the hair, if you will.

ANIMESH SINHA, MD, PhD: Yes, in some percentage of follicles.

DAVID FOLK THOMAS: And as I mentioned, I have 100,000 hairs up here right now? Is that right?

ANGELA CHRISTIANO, PhD: You look pretty good.

DAVID FOLK THOMAS: In the course of this I might lose one of them, based on the 50 per day, if we extrapolate that out? There it goes.

ANIMESH SINHA, MD, PhD: Right. The average daily hair loss is about 50 to 100 per day. Now, if there's a consistent loss of more than 150 hairs per day, if that's persistent and consistent over some time, then that might push us into the disease state, temporary or otherwise, and that would be termed alopecia.

DAVID FOLK THOMAS: How long can hair grow? For men, I guess we cut it at a certain point, but is there a limit if I decided not to get a hair cut, how long it could grow, and then will it stop eventually?

ANGELA CHRISTIANO, PhD: You do hear people say, "My hair only grows to this length, and never any longer," and then you hear people who say, "I once grew my hair down to my ankles, and it could have kept going."  It's believed that the length of anagen, the length of the growth phase, is actually different in different people, and we don't know exactly what might determine that, although of course we believe it's genetic.

DAVID FOLK THOMAS: If anagen can be -- is it six to ten years, usually, for that stage?

ANIMESH SINHA, MD, PhD: It varies, anywhere from two to maybe even ten years, and that's, as Angela said, precisely that the length of hair is determined by the length of time that the hair follicle is in anagen or growing phase.

DAVID FOLK THOMAS: So does everybody's hair grow at basically the same rate, and then if that's the case, then if you have a shorter anagen phase that therefore you would only be able to grow your hair to a certain length, somebody with a longer phase?

ANIMESH SINHA, MD, PhD: In general, that is true, that the rate, the actual rate of the hair growth, is pretty constant -- anywhere between 0.3 to 0.5, so a third to a half a millimeter a day, and that works out to about a centimeter a month or six to seven inches per year, and that varies a little bit, depending on the site. For example, the hairs grow a little faster on the top of our scalp versus the beard region, but that's pretty uniform. And then what determines the length of hair, again, as we talked about, is the length of anagen, and a number of factors, including genetic factors, related to age, race, sometimes medications, even seasonal variation, affect the length of anagen and affect how long the hair will grow.

DAVID FOLK THOMAS: Just to wrap things up, you see people with straight hair, like myself, others very curly hair. What determines what's going on once it leaves the follicle?

ANIMESH SINHA, MD, PhD: The shape of the hair, whether it's straight or curly, is dependent on the shape of the follicle itself, so when the follicle is circular or round, the hair is straight. When the follicle looked in cross-section is oval or elliptical, that results in a curly hair at the surface.

DAVID FOLK THOMAS: All right. That's all the time we have on this webcast. We hope you've learned something. My name is David Folk Thomas, and we'll see you next time.

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